Melatonin stimulates the growth of new bone around implants in the tibia of rabbits
Identifieur interne : 000943 ( Main/Exploration ); précédent : 000942; suivant : 000944Melatonin stimulates the growth of new bone around implants in the tibia of rabbits
Auteurs : José L. Calvo Uirado [Espagne] ; María P. Ramírez Ernández [Espagne] ; Gerardo G Mez Oreno [Espagne] ; José E. Maté Nchez [Espagne] ; Rafael Delgado Uiz [Espagne] ; Javier Guardia [Espagne] ; Laura L Pez Arí [Espagne] ; Antonio Barone [Italie] ; Antonio J. Ortiz Uiz [Espagne] ; José M. Martínez Onzález [Espagne] ; Luis A. Bravo [Espagne]Source :
- Journal of Pineal Research [ 0742-3098 ] ; 2010-11.
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Abstract
Abstract: This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.
Url:
DOI: 10.1111/j.1600-079X.2010.00801.x
Affiliations:
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Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Italie</li></country><region><li>Andalousie</li></region><settlement><li>Grenade (Espagne)</li></settlement><orgName><li>Université de Grenade</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Calvo Uirado, Jose L" sort="Calvo Uirado, Jose L" uniqKey="Calvo Uirado J" first="José L." last="Calvo Uirado">José L. Calvo Uirado</name></noRegion><name sortKey="Bravo, Luis A" sort="Bravo, Luis A" uniqKey="Bravo L" first="Luis A." last="Bravo">Luis A. Bravo</name><name sortKey="Delgado Uiz, Rafael" sort="Delgado Uiz, Rafael" uniqKey="Delgado Uiz R" first="Rafael" last="Delgado Uiz">Rafael Delgado Uiz</name><name sortKey="G Mez Oreno, Gerardo" sort="G Mez Oreno, Gerardo" uniqKey="G Mez Oreno G" first="Gerardo" last="G Mez Oreno">Gerardo G Mez Oreno</name><name sortKey="Guardia, Javier" sort="Guardia, Javier" uniqKey="Guardia J" first="Javier" last="Guardia">Javier Guardia</name><name sortKey="L Pez Ari, Laura" sort="L Pez Ari, Laura" uniqKey="L Pez Ari L" first="Laura" last="L Pez Arí">Laura L Pez Arí</name><name sortKey="Martinez Onzalez, Jose M" sort="Martinez Onzalez, Jose M" uniqKey="Martinez Onzalez J" first="José M." last="Martínez Onzález">José M. Martínez Onzález</name><name sortKey="Mate Nchez, Jose E" sort="Mate Nchez, Jose E" uniqKey="Mate Nchez J" first="José E." last="Maté Nchez">José E. Maté Nchez</name><name sortKey="Ortiz Uiz, Antonio J" sort="Ortiz Uiz, Antonio J" uniqKey="Ortiz Uiz A" first="Antonio J." last="Ortiz Uiz">Antonio J. Ortiz Uiz</name><name sortKey="Ramirez Ernandez, Maria P" sort="Ramirez Ernandez, Maria P" uniqKey="Ramirez Ernandez M" first="María P." last="Ramírez Ernández">María P. Ramírez Ernández</name></country><country name="Italie"><noRegion><name sortKey="Barone, Antonio" sort="Barone, Antonio" uniqKey="Barone A" first="Antonio" last="Barone">Antonio Barone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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